Search results for " kinetics"
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Interaction kinetics describes the interaction between one or more components. After the interaction, the components leave each other unchanged as opposed to enzyme kinetics. The rate of association …
Article
Modeling the Degradation of mAb Therapeutics
This article in the Elements of Biopharmaceutical Production discusses the kinetics of these degradation pathways as well as the insights they reveal that can help developers ensure the stability of b…
Article
Leveraging Computational Models of Glycosylation for Biopharma QA
Close collaboration between academic and industrial groups is vital to ensuring glycosylation models are fit for deployment.
By Ioscani Jiménez del Val
Good Studio/S…
Article
Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Surface plasmon resonance is helping define bispecific antibodies, the next-generation of biopharma therapeutics.
By Robert Karlsson
Abstract
Biotherapeutic antibodies are still the larg…
Article
Ligand-Binding Assays and the Determination of Biosimilarity
During biosimilar development, it is necessary to demonstrate that the physicochemical properties, efficacy, and safety (e.g., immunogenicity) of the biosimilar are similar to those of the …
Article
Resolving a bottleneck in screening and characterization of recombinant antibody fragments using Biacore 4000
A subset from this screen was selected for analysis with the 2-over-2 kinetics approach. This method provides rapid screening in combination with data-rich selection of fragments with high affinity an…
Article
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
Once we've defined these fluid mechanical effects, we can then start to provide an insight into binding thermodynamics and kinetics. This we can do with rather simple, gradient elution experiments for…
Article
Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.
By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani
Drug development is …
Article
Using Digital Twins to Model Process Chromatography
…ystem at hand, using deceptively simple fundamental natural laws from the fields of fluid mechanics, kinetics, and thermodynamics. With these base processes understood, the complex, emergent behavior…
Article
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